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News

1 March 2024

New review: Acute and non-acute decompensation of liver cirrhosis

New research challenges the current view of decompensated cirrhosis. Acute and Non-Acute Decompensation pathways offer nuanced perspectives. This review by Martin Schulz, Paolo Angeli and Jonel Trebicka (WWU) explores these insights, guiding future clinical approaches.

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News

27 February 2024

Masterclass: Health economic studies in liver diseases by Professor Isabelle Durand-Zaleski

Health economics – a topic quite far from most people’s everyday preoccupations and concerns. But it needn’t be! Discover answers to questions like: What do health economics and shopping for a hoodie have in common? How do you calculate QALYs? Why are drug prices so high and when is a treatment “too expensive”?

Understanding how policy makers utilize health economic studies is not only interesting for healthcare professionals, but also for citizens.

Watch the masterclass on health economic studies in liver diseases by Professor Isabelle Durand-Zaleski, from partner AP-HP:

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Events

18 - 19 April 2024

Upcoming: DECISION’s 9th Steering Committee Meeting

Our 9th Steering Committee (SC) Meeting will take place in beautiful Münster, Germany, hosted by our partner, the Münster University Hospital. During the 1.5 meeting days, we'll be discussing the project's progress, its achievements so far, and plan ahead for the next months to come.

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Our Vision

DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.

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Why it matters

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.