In this video, we explore how emergency granulopoiesis, the rapid production of immune cells during crisis, becomes defective in acute liver failure. Using the analogy of a fire station releasing firefighters, Ferran Aguilar, biostatistician and first author of the accompanying paper, illustrates how the body’s emergency response can spiral into a vicious cycle: liver injury triggers immune chaos, which in turn fuels further damage.

Our findings reveal that this is not simply an exaggerated immune response. Instead, the immune “factory” begins producing the wrong cells at the wrong time, contributing to disease progression.

Understanding this defective emergency program opens the door to new therapeutic strategies, not to suppress the immune system, but to help it generate the right response when it is needed most.

🎥 Watch the full video:

📖 Read the publication Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.

How do you navigate data repositories? How to access datasets responsibly, and make the most of bioinformatics resources?
The newly published masterclass titled Data repositories and their access and publication rights covers the history of databases, an overview of repositories used in the DECISION project, and provides a hands-on recipe on how to make the best use out of different types of data.

Speakers: Dr. David Gómez-Cabrero – Associate Professor, KAUST, Cristina Sánchez Garrido – Head of Data Management Center, EF CLIF, and Ferran Aguilar – Biostatistician, EF CLIF

Watch the masterclass here: https://youtu.be/aoA0WC1yaqs

This session complements our previous DECISION masterclass on clinical bioinformatics. Watch it here: https://youtu.be/UBm1_JGhw6M